Ontology highlight
ABSTRACT:
SUBMITTER: Kim JW
PROVIDER: S-EPMC4213765 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Molecules and cells 20140929 10
The epithelial cell adhesion molecule (EpCAM, also known as CD326) is a transmembrane glycoprotein that is specifically detected in most adenocarcinomas and cancer stem cells. In this study, we performed a Cell systematic evolution of ligands by exponential enrichment (SELEX) experiment to isolate the aptamers against EpCAM. After seven round of Cell SELEX, we identified several aptamer candidates. Among the selected aptamers, EP166 specifically binds to cells expressing EpCAM with an equilibriu ...[more]