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ABSTRACT: Background
To investigate the antidiabetic effects of hydrolyzed ginseng extract (HGE) for Korean participants in an 8-wk, randomized, double-blinded, placebo-controlled clinical trial.Methods
Impaired fasting glucose participants [fasting plasma glucose (FPG) ≥ 5.6mM or < 6.9mM] who had not been diagnosed with any disease and met the inclusion criteria were recruited for this study. The 23 participants were randomly divided into either the HGE (n = 12, 960 mg/d) or placebo (n = 11) group. Outcomes included measurements of efficacy (FPG, postprandial glucose, fasting plasma insulin, postprandial insulin, homeostatic model assessment-insulin resistance, and homeostatic model assessment-β) and safety (adverse events, laboratory tests, electrocardiogram, and vital signs).Results
After 8 wk of HGE supplementation, FPG and postprandial glucose were significantly decreased in the HGE group compared to the placebo group. No clinically significant changes in any safety parameter were observed. Our study revealed that HGE is a potent antidiabetic agent that does not produce noticeable adverse effects.Conclusion
HGE supplementation may be effective for treating impaired fasting glucose individuals.
SUBMITTER: Park SH
PROVIDER: S-EPMC4213818 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Park Soo-Hyun SH Oh Mi-Ra MR Choi Eun-Kyung EK Kim Min-Gul MG Ha Ki-Chan KC Lee Seung-Kwon SK Kim Young-Gon YG Park Byung-Hyun BH Kim Dal-Sik DS Chae Soo-Wan SW
Journal of ginseng research 20140523 4
<h4>Background</h4>To investigate the antidiabetic effects of hydrolyzed ginseng extract (HGE) for Korean participants in an 8-wk, randomized, double-blinded, placebo-controlled clinical trial.<h4>Methods</h4>Impaired fasting glucose participants [fasting plasma glucose (FPG) ≥ 5.6mM or < 6.9mM] who had not been diagnosed with any disease and met the inclusion criteria were recruited for this study. The 23 participants were randomly divided into either the HGE (n = 12, 960 mg/d) or placebo (n = ...[more]