Purinergic regulation of neutrophil chemotaxis.
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ABSTRACT:
SUBMITTER: Junger WG
PROVIDER: S-EPMC4214070 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
Purinergic regulation of neutrophil chemotaxis.
Cellular and molecular life sciences : CMLS 20080801 16
Chemotaxis allows polymorphonuclear neutrophils (PMN) to rapidly reach infected and inflamed sites. However, excessive influx of PMN damages host tissues. Better knowledge of the mechanisms that control PMN chemotaxis may lead to improved treatments of inflammatory diseases. Recent findings suggest that ATP and adenosine are involved in PMN chemotaxis. Therefore, these purinergic signaling processes may be suitable targets for novel therapeutic approaches to ameliorate host tissue damage. ...[more]
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