Role of DNA methylation and the DNA methyltransferases in learning and memory.
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ABSTRACT:
SUBMITTER: Morris MJ
PROVIDER: S-EPMC4214178 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Role of DNA methylation and the DNA methyltransferases in learning and memory.
Morris Michael J MJ Monteggia Lisa M LM
Dialogues in clinical neuroscience 20140901 3
Dynamic regulation of chromatin structure in postmitotic neurons plays an important role in learning and memory. Methylation of cytosine nucleotides has historically been considered the strongest and least modifiable of epigenetic marks. Accumulating recent data suggest that rapid and dynamic methylation and demethylation of specific genes in the brain may play a fundamental role in learning, memory formation, and behavioral plasticity. The current review focuses on the emergence of data that su ...[more]
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