The GABAergic parafacial zone is a medullary slow wave sleep-promoting center.
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ABSTRACT:
SUBMITTER: Anaclet C
PROVIDER: S-EPMC4214681 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
The GABAergic parafacial zone is a medullary slow wave sleep-promoting center.
Anaclet Christelle C Ferrari Loris L Arrigoni Elda E Bass Caroline E CE Saper Clifford B CB Lu Jun J Fuller Patrick M PM
Nature neuroscience 20140817 9
Work in animals and humans has suggested the existence of a slow wave sleep (SWS)-promoting/electroencephalogram (EEG)-synchronizing center in the mammalian lower brainstem. Although sleep-active GABAergic neurons in the medullary parafacial zone (PZ) are needed for normal SWS, it remains unclear whether these neurons can initiate and maintain SWS or EEG slow-wave activity (SWA) in behaving mice. We used genetically targeted activation and optogenetically based mapping to examine the downstream ...[more]
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