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Tuberculosis recurrence in a high incidence setting for HIV and tuberculosis in Brazil.


ABSTRACT: To compare epidemiological data between recurrent cases after cure (RC), distinguishing relapse from reinfection, after dropout (RD) and new cases (NC) in an ambulatory setting in a TB-endemic country.Records of patients who started treatment for pulmonary TB between 2004 and 2010 in a TB clinic were reviewed. Epidemiological data were analyzed. Spoligotyping and MIRU patterns were used to determine relapse or reinfection in 13 RC available.Of the eligible group (1449), 1060 were NC (73.2%), among the recurrent cases, 203 (14%) were RC and 186 (12.8%) were RD. Of RC, 171 (84.2%) occurred later than 6 months after a previous episode, 13 had available DNA, in 4 (30.7%) the disease was attributed to reinfection and in 9 (69.3%), to relapse. Comparing RC to NC, HIV (p?

SUBMITTER: Unis G 

PROVIDER: S-EPMC4215011 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Tuberculosis recurrence in a high incidence setting for HIV and tuberculosis in Brazil.

Unis Gisela G   Ribeiro Andrezza Wolowski AW   Esteves Leonardo Souza LS   Spies Fernanda Sá FS   Picon Pedro Dornelles PD   Dalla Costa Elis Regina ER   Rossetti Maria Lucia Rosa ML  

BMC infectious diseases 20141024


<h4>Background</h4>To compare epidemiological data between recurrent cases after cure (RC), distinguishing relapse from reinfection, after dropout (RD) and new cases (NC) in an ambulatory setting in a TB-endemic country.<h4>Methods</h4>Records of patients who started treatment for pulmonary TB between 2004 and 2010 in a TB clinic were reviewed. Epidemiological data were analyzed. Spoligotyping and MIRU patterns were used to determine relapse or reinfection in 13 RC available.<h4>Results</h4>Of t  ...[more]

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