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The circuitry of abulia: insights from functional connectivity MRI.


ABSTRACT:

Background

Functional imaging and lesion studies have associated willed behavior with the anterior cingulate cortex (ACC). Abulia is a syndrome characterized by apathy and deficiency of motivated behavior. Abulia is most frequently associated with ACC damage, but also occurs following damage to subcortical nuclei (striatum, globus pallidus, thalamic nuclei). We present resting state functional connectivity MRI (fcMRI) data from an individual who suffered a stroke leading to abulia. We hypothesized that, although structural imaging revealed no damage to the patient's ACC, fcMRI would uncover aberrant function in this region and in the relevant cortical networks.

Methods

Resting state correlations in the patient's gray matter were compared to those of age-matched controls. Using a novel method to identify abnormal patterns of functional connectivity in single subjects, we identified areas and networks with aberrant connectivity.

Results

Networks associated with memory (default mode network) and executive function (cingulo-opercular network) were abnormal. The patient's anterior cingulate was among the areas showing aberrant functional connectivity. In a rescan 3 years later, deficits remained stable and fcMRI findings were replicated.

Conclusions

These findings suggest that the aberrant functional connectivity mapping approach described may be useful for linking stroke symptoms to disrupted network connectivity.

SUBMITTER: Siegel JS 

PROVIDER: S-EPMC4215525 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

The circuitry of abulia: insights from functional connectivity MRI.

Siegel J S JS   Snyder A Z AZ   Metcalf N V NV   Fucetola R P RP   Hacker C D CD   Shimony J S JS   Shulman G L GL   Corbetta M M  

NeuroImage. Clinical 20140923


<h4>Background</h4>Functional imaging and lesion studies have associated willed behavior with the anterior cingulate cortex (ACC). Abulia is a syndrome characterized by apathy and deficiency of motivated behavior. Abulia is most frequently associated with ACC damage, but also occurs following damage to subcortical nuclei (striatum, globus pallidus, thalamic nuclei). We present resting state functional connectivity MRI (fcMRI) data from an individual who suffered a stroke leading to abulia. We hy  ...[more]

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