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Imparting superhydrophobicity to biodegradable poly(lactide-co-glycolide) electrospun meshes.

ABSTRACT: The synthesis of a family of new poly(lactic acid-co-glycerol monostearate) (PLA-PGC18) copolymers and their use as biodegradable polymer dopants is reported to enhance the hydrophobicity of poly(lactic acid-co-glycolic acid) (PLGA) nonwoven meshes. Solutions of PLGA are doped with PLA-PGC18 and electrospun to form meshes with micrometer-sized fibers. Fiber diameter, percent doping, and copolymer composition influence the nonwetting nature of the meshes and alter their mechanical (tensile) properties. Contact angles as high as 160° are obtained with 30% polymer dopant. Lastly, these meshes are nontoxic, as determined by an NIH/3T3 cell biocompatibility assay, and displayed a minimal foreign body response when implanted in mice. In summary, a general method for constructing biodegradable fibrous meshes with tunable hydrophobicity is described for use in tissue engineering and drug delivery applications.

SUBMITTER: Kaplan JA 

PROVIDER: S-EPMC4215912 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Imparting superhydrophobicity to biodegradable poly(lactide-co-glycolide) electrospun meshes.

Kaplan Jonah A JA   Lei Hongyi H   Liu Rong R   Padera Robert R   Colson Yolonda L YL   Grinstaff Mark W MW  

Biomacromolecules 20140620 7

The synthesis of a family of new poly(lactic acid-co-glycerol monostearate) (PLA-PGC18) copolymers and their use as biodegradable polymer dopants is reported to enhance the hydrophobicity of poly(lactic acid-co-glycolic acid) (PLGA) nonwoven meshes. Solutions of PLGA are doped with PLA-PGC18 and electrospun to form meshes with micrometer-sized fibers. Fiber diameter, percent doping, and copolymer composition influence the nonwetting nature of the meshes and alter their mechanical (tensile) prope  ...[more]