Ontology highlight
ABSTRACT:
SUBMITTER: Chang YH
PROVIDER: S-EPMC4216105 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Chang Yung-Heng YH Sun Yi Henry YH
PloS one 20141031 10
Morphogens are signaling molecules that regulate growth and patterning during development by forming a gradient and activating different target genes at different concentrations. The extracellular distribution of morphogens is tightly regulated, with the Drosophila morphogen Wingless (Wg) relying on Dally-like (Dlp) and transcytosis for its distribution. However, in the absence of Dlp or endocytic activity, Wg can still move across cells along the apical (Ap) surface. We identified a novel secre ...[more]