Ontology highlight
ABSTRACT:
SUBMITTER: Xin A
PROVIDER: S-EPMC4216683 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Xin Aiguo A Zhu Mingwang M Peng Zhenqi Z Hu Qi Q Shi Chenhong C Liao Defang D Wang Jihua J Li Huachun H
International journal of genomics 20141019
The molecular basis of attenuation of foot-and-mouth disease virus (FMDV) serotype Asia1 ZB strain remains unknown. To understand the genetic changes of attenuation, we compared the entire genomes of three different rabbit-passaged attenuated ZB strains (ZB/CHA/58(att), ZBRF168, and ZBRF188) and their virulent parental strains (ZBCF22 and YNBS/58). The results showed that attenuation may be brought about by 28 common amino acid substitutions in the coding region, with one nucleotide point mutati ...[more]