The landscape of human STR variation.
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ABSTRACT:
SUBMITTER: Willems T
PROVIDER: S-EPMC4216929 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
The landscape of human STR variation.
Willems Thomas T Gymrek Melissa M Highnam Gareth G Mittelman David D Erlich Yaniv Y
Genome research 20140818 11
Short tandem repeats are among the most polymorphic loci in the human genome. These loci play a role in the etiology of a range of genetic diseases and have been frequently utilized in forensics, population genetics, and genetic genealogy. Despite this plethora of applications, little is known about the variation of most STRs in the human population. Here, we report the largest-scale analysis of human STR variation to date. We collected information for nearly 700,000 STR loci across more than 10 ...[more]
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