Ontology highlight
ABSTRACT:
SUBMITTER: Davis AR
PROVIDER: S-EPMC4217412 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Davis Amber R AR Gohara David W DW Yap Mee-Ngan F MN
Proceedings of the National Academy of Sciences of the United States of America 20141013 43
The prevailing "plug-in-the-bottle" model suggests that macrolide antibiotics inhibit translation by binding inside the ribosome tunnel and indiscriminately arresting the elongation of every nascent polypeptide after the synthesis of six to eight amino acids. To test this model, we performed a genome-wide analysis of translation in azithromycin-treated Staphylococcus aureus. In contrast to earlier predictions, we found that the macrolide does not preferentially induce ribosome stalling near the ...[more]