Ontology highlight
ABSTRACT:
SUBMITTER: Choe J
PROVIDER: S-EPMC4217471 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Choe Junho J Ryu Incheol I Park Ok Hyun OH Park Joori J Cho Hana H Yoo Jin Seon JS Chi Sung Wook SW Kim Min Kyung MK Song Hyun Kyu HK Kim Yoon Ki YK
Proceedings of the National Academy of Sciences of the United States of America 20141013 43
It has long been considered that intron-containing (spliced) mRNAs are translationally more active than intronless mRNAs (identical mRNA not produced by splicing). The splicing-dependent translational enhancement is mediated, in part, by the exon junction complex (EJC). Nonetheless, the molecular mechanism by which each EJC component contributes to the translational enhancement remains unclear. Here, we demonstrate the previously unappreciated role of eukaryotic translation initiation factor 4AI ...[more]