Ontology highlight
ABSTRACT:
SUBMITTER: Weinhold N
PROVIDER: S-EPMC4217527 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Weinhold Nils N Jacobsen Anders A Schultz Nikolaus N Sander Chris C Lee William W
Nature genetics 20140928 11
Cancer primarily develops because of somatic alterations in the genome. Advances in sequencing have enabled large-scale sequencing studies across many tumor types, emphasizing the discovery of alterations in protein-coding genes. However, the protein-coding exome comprises less than 2% of the human genome. Here we analyze the complete genome sequences of 863 human tumors from The Cancer Genome Atlas and other sources to systematically identify noncoding regions that are recurrently mutated in ca ...[more]