Estimation of glomerular filtration rate from serum creatinine and cystatin C in octogenarians and nonagenarians.

ABSTRACT:

Background

Equations to estimate GFR have not been well validated in the elderly and may misclassify persons with chronic kidney disease (CKD). We measured GFR and compared the performance of the Modification of Diet in Renal Disease (MDRD), the Chronic Kidney Disease-Epidemiology Collaboration (CKD-Epi) and the Berlin Initiative Study (BIS) equations based on creatinine and/or cystatin C in octogenarians and nonagenarians.

Methods

Using cross-sectional analysis we assessed 95 very elderly persons (mean 85 years) living in the community. GFR was measured by iohexol (mGFR) and compared with estimates using six equations: MDRD, CKD-Epi_creatinine, CKD-Epi_cystatin, CKD-Epi_creatinine-cystatin, BIS_creatinine and BIS_creatinine-cystatin.

Results

Mean mGFR was 55 (range,1

SUBMITTER: Lopes MB 

PROVIDER: S-EPMC4219437 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature