Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder.
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ABSTRACT:
SUBMITTER: Witt SH
PROVIDER: S-EPMC4219535 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
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Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder.
Witt Stephanie H SH Kleindienst Nikolaus N Frank Josef J Treutlein Jens J Mühleisen Thomas T Degenhardt Franziska F Jungkunz Martin M Krumm Bertram B Cichon Sven S Tadic André A Dahmen Norbert N Schwarze Cornelia E CE Schott Björn B Dietl Lydia L Nöthen Markus M MM Mobascher Arian A Lieb Klaus K Roepke Stefan S Rujescu Dan D Rietschel Marcella M Schmahl Christian C Bohus Martin M
Psychiatric genetics 20141201 6
The objective of this study was to investigate the hypothesis that borderline personality disorder (BPD) and bipolar disorder (BD) share genetic variation through analysis of known genetic risk factors for BD in a well-characterized BPD case-control cohort. Genotyping of five genome-wide significant variants identified for BD (in CACNA1C, ANK3, and ODZ4) was performed in 673 BPD cases and 748 controls. A nominally significant association with BPD was found for rs1006737 in CACNA1C (P=0.0498). Se ...[more]
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