Itch is required for lateral line development in zebrafish.
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ABSTRACT:
SUBMITTER: Angers A
PROVIDER: S-EPMC4219781 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Itch is required for lateral line development in zebrafish.
Angers Annie A Drapeau Pierre P
PloS one 20141104 11
The zebrafish posterior lateral line is formed during early development by the deposition of neuromasts from a migrating primordium. The molecular mechanisms regulating the regional organization and migration of the primordium involve interactions between Fgf and Wnt/β-catenin signaling and the establishment of specific cxcr4b and cxcr7b cytokine receptor expression domains. Itch has been identified as a regulator in several different signaling pathways, including Wnt and Cxcr4 signaling. We ide ...[more]
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