Ontology highlight
ABSTRACT:
SUBMITTER: Soesbe TC
PROVIDER: S-EPMC4219925 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Soesbe Todd C TC Ratnakar S James SJ Milne Mark M Zhang Shanrong S Do Quyen N QN Kovacs Zoltan Z Sherry A Dean AD
Magnetic resonance in medicine 20140301 3
<h4>Purpose</h4>The water molecule exchange rates in a series of DyDOTA-(amide)X chelates were fine-tuned to maximize the effects of T2-exchange line broadening and improve T2 contrast.<h4>Methods</h4>Four DyDOTA-(amide)X chelates having a variable number of glycinate side-arms were prepared and characterized as T2-exchange agents. The nonexchanging DyTETA chelate was also used to measure the bulk water T2 reduction due solely to T2*. The total transverse relaxivity (r2tot) at 22, 37, and 52°C f ...[more]