Ontology highlight
ABSTRACT:
SUBMITTER: Speciale G
PROVIDER: S-EPMC4220041 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Speciale Gaetano G Thompson Andrew J AJ Davies Gideon J GJ Williams Spencer J SJ
Current opinion in structural biology 20140710
Glycoside hydrolases (GHs) are classified into >100 sequence-based families. These enzymes process a wide variety of complex carbohydrates with varying stereochemistry at the anomeric and other ring positions. The shapes that these sugars adopt upon binding to their cognate GHs, and the conformational changes that occur along the catalysis reaction coordinate is termed the conformational itinerary. Efforts to define the conformational itineraries of GHs have focussed upon the critical points of ...[more]