1,3-Butadiene exposure and metabolism among Japanese American, Native Hawaiian, and White smokers.

ABSTRACT:

Background

We hypothesize that the differences in lung cancer risk in Native Hawaiians, whites, and Japanese Americans may, in part, be due to variation in the metabolism of 1,3-butadiene, one of the most abundant carcinogens in cigarette smoke.

Methods

We measured two biomarkers of 1,3-butadiene exposure, monohydroxybutyl mercapturic acid (MHBMA) and dihydroxybutyl mercapturic acid (DHBMA), in overnight urine samples among 584 Native Hawaiians, Japanese Americans, and white smokers in Hawaii. These values were normalized to creatinine levels. Ethnic-specific geometric means were compared adjusting for age at urine collection, sex, body mass index, and nicotine equivalents (a marker of total nicotine uptake).

Results

We found that mean urinary MHBMA differed by race/e

SUBMITTER: Park SL 

PROVIDER: S-EPMC4220266 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature