Ontology highlight
ABSTRACT:
SUBMITTER: Scheffler JM
PROVIDER: S-EPMC4220488 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Nature communications 20141022
The receptor tyrosine kinase Flt3 and its ligand are crucial for dendritic cell (DC) homeostasis by activating downstream effectors including mammalian target of Rapamycin (mTOR) signalling. LAMTOR2 is a member of the Ragulator/LAMTOR complex known to regulate mTOR and extracellular signal-regulated kinase activation on the late endosome as well as endosomal biogenesis. Here we show in mice that conditional ablation of LAMTOR2 in DCs results in a severe disturbance of the DC compartment caused b ...[more]