Ontology highlight
ABSTRACT:
SUBMITTER: Sommer WH
PROVIDER: S-EPMC4220658 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Frontiers in integrative neuroscience 20141105
The striatum plays a key role in motor learning. Striatal function depends strongly on dopaminergic neurotransmission, but little is known about neuroadaptions of the dopamine system during striatal learning. Using an established task that allows differentiation between acquisition and consolidation of motor learning, we here investigate D1 and D2-like receptor binding and transcriptional levels after initial and long-term training of mice. We found profound reduction in D1 binding within the do ...[more]