Ontology highlight
ABSTRACT:
SUBMITTER: Glykys J
PROVIDER: S-EPMC4220679 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Glykys J J Dzhala V V Egawa K K Balena T T Saponjian Y Y Kuchibhotla K V KV Bacskai B J BJ Kahle K T KT Zeuthen T T Staley K J KJ
Science (New York, N.Y.) 20140201 6171
Neuronal intracellular chloride concentration [Cl(-)](i) is an important determinant of γ-aminobutyric acid type A (GABA(A)) receptor (GABA(A)R)-mediated inhibition and cytoplasmic volume regulation. Equilibrative cation-chloride cotransporters (CCCs) move Cl(-) across the membrane, but accumulating evidence suggests factors other than the bulk concentrations of transported ions determine [Cl(-)](i). Measurement of [Cl(-)](i) in murine brain slice preparations expressing the transgenic fluoropho ...[more]