Ontology highlight
ABSTRACT:
SUBMITTER: Lacerda M
PROVIDER: S-EPMC4220805 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Lacerda Miguel M Moore Penny L PL Ngandu Nobubelo K NK Seaman Michael M Gray Elin S ES Murrell Ben B Krishnamoorthy Mohan M Nonyane Molati M Madiga Maphuti M Wibmer Constantinos Kurt CK Sheward Daniel D Bailer Robert T RT Gao Hongmei H Greene Kelli M KM Karim Salim S Abdool SS Mascola John R JR Korber Bette T M BT Montefiori David C DC Morris Lynn L Williamson Carolyn C Seoighe Cathal C
Virology journal 20131202
<h4>Background</h4>Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a preventative vaccine.<h4>Methods</h4>We have developed a computational approach that can identify key amino acids within the HIV-1 envelope glycoprotein that influence sensitivity to broadly cross-neutralizing antibodies. Given a sequence alignment and neutralization titers for a panel of viruses, the method works by fitting a phylogen ...[more]