Unknown

Dataset Information

0

A PCR-based microwell-plate hybrid capture assay for high-risk human papillomavirus.


ABSTRACT: Human papillomavirus (HPV) is associated with cervical cancer. In this study, we developed a high-throughput microwell-plate hybrid capture (MPHC) method for epidemiological studies of high-risk HPV (HRHPV). The results with 1238 cervical specimens from female outpatients showed a concordance rate of 94.3 % between the MPHC and Hybrid Capture II assay. The MPHC assay showed an average HRHPV rate of 29.3 % for high-risk populations in populous cities of China. The established MPHC assay could sensitively and specifically detect 13 types of HRHPV and is suitable for large-scale screening, especially in areas where real-time PCR or fluorescence equipment is unavailable.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4221605 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC229795 | biostudies-other
| S-EPMC2725686 | biostudies-literature
| S-EPMC7911513 | biostudies-literature
| S-EPMC2519476 | biostudies-literature
| S-EPMC3957775 | biostudies-literature
| S-EPMC3993637 | biostudies-literature
| S-EPMC8398598 | biostudies-literature
| S-EPMC1489390 | biostudies-literature
| S-EPMC165384 | biostudies-literature
| S-EPMC6650390 | biostudies-literature