Ontology highlight
ABSTRACT:
SUBMITTER: Gaboriaud C
PROVIDER: S-EPMC4222235 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Gaboriaud Christine C Ling Wai Li WL Thielens Nicole M NM Bally Isabelle I Rossi Véronique V
Frontiers in immunology 20141106
The classical complement pathway is initiated by the large (~800 kDa) and flexible multimeric C1 complex. Its catalytic function is triggered by the proteases hetero-tetramer C1r2s2, which is associated to the C1q sensing unit, a complex assembly of 18 chains built as a hexamer of heterotrimers. Initial pioneering studies gained insights into the main architectural principles of the C1 complex. A dissection strategy then provided the high-resolution structures of its main functional and/or struc ...[more]