Ontology highlight
ABSTRACT:
SUBMITTER: Lee W
PROVIDER: S-EPMC4222369 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Lee Wooje W Yun Jung-Mi JM Woods Rima R Dunaway Keith K Yasui Dag H DH Lasalle Janine M JM Gong Qizhi Q
Human molecular genetics 20140709 23
During postnatal development, neuronal activity controls the remodeling of initially imprecise neuronal connections through the regulation of gene expression. MeCP2 binds to methylated DNA and modulates gene expression during neuronal development and MECP2 mutation causes the autistic disorder Rett syndrome. To investigate a role for MeCP2 in neuronal circuit refinement and to identify activity-dependent MeCP2 transcription regulations, we leveraged the precise organization and accessibility of ...[more]