Ontology highlight
ABSTRACT:
SUBMITTER: Gorbatyuk V
PROVIDER: S-EPMC4222533 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Gorbatyuk Vitaliy V Nguyen Khiem K Podolnikova Nataly P NP Deshmukh Lalit L Lin Xiaochen X Ugarova Tatiana P TP Vinogradova Olga O
Biochemistry 20141022 43
Over the last two decades, our knowledge concerning intracellular events that regulate integrin's affinity to their soluble ligands has significantly improved. However, the mechanism of adhesion-induced integrin clustering and development of focal complexes, which could further mature to form focal adhesions, still remains under-investigated. Here we present a structural model of tandem IgC2 domains of skelemin in complex with the cytoplasmic tails of integrin αIIbβ3. The model of tertiary assem ...[more]