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Genetic mutations in influenza H3N2 viruses from a 2012 epidemic in Southern China.

ABSTRACT: BACKGROUND: An influenza H3N2 epidemic occurred throughout Southern China in 2012. METHODS: We analyzed the hemagglutinin (HA) and neuraminidase (NA) genes of influenza H3N2 strains isolated between 2011-2012 from Guangdong. Mutation sites, evolutionary selection, antigenic sites, and N-glycosylation within these strains were analyzed. RESULTS: The 2011-2012 Guangdong strains contained the HA-A214S, HA-V239I, HA-N328S, NA-L81P, and NA-D93G mutations, similar to those seen in the A/ Perth/16/2009 influenza strain. The HA-NSS061-063 and NNS160-162 glycosylation sites were prevalent among the 2011-2012 Guangdong strains but the NA-NRS402-404 site was deleted. Antigenically, there was a four-fold difference between A/Perth/16/2009 -like strains and the 2011-2012 Guangdong strains. CONCLUSION: Antigenic drift of the H3N2 subtype contributed to the occurrence of the Southern China influenza epidemic of 2012.

SUBMITTER: Zhong J

PROVIDER: S-EPMC4222568 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Genetic mutations in influenza H3N2 viruses from a 2012 epidemic in Southern China.

Zhong Jing J Liang Lijun L Huang Ping P Zhu Xiaolan X Zou Lirong L Yu Shouyi S Zhang Xin X Zhang Yonghui Y Ni Hanzhong H Yan Jin J

Virology journal 20131126

<h4>Background</h4>An influenza H3N2 epidemic occurred throughout Southern China in 2012.<h4>Methods</h4>We analyzed the hemagglutinin (HA) and neuraminidase (NA) genes of influenza H3N2 strains isolated between 2011-2012 from Guangdong. Mutation sites, evolutionary selection, antigenic sites, and N-glycosylation within these strains were analyzed.<h4>Results</h4>The 2011-2012 Guangdong strains contained the HA-A214S, HA-V239I, HA-N328S, NA-L81P, and NA-D93G mutations, similar to those seen in t ...[more]

PMID: 24279698

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