Ontology highlight
ABSTRACT:
SUBMITTER: Sardiu ME
PROVIDER: S-EPMC4223495 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Sardiu Mihaela E ME Smith Karen T KT Groppe Brad D BD Gilmore Joshua M JM Saraf Anita A Egidy Rhonda R Peak Allison A Seidel Chris W CW Florens Laurence L Workman Jerry L JL Washburn Michael P MP
Molecular & cellular proteomics : MCP 20140729 11
Histone deacetylases (HDACs) are targets for cancer therapy. Suberoylanilide hydroxamic acid (SAHA) is an HDAC inhibitor approved by the U.S. Food and Drug Administration for the treatment of cutaneous T-cell lymphoma. To obtain a better mechanistic understanding of the Sin3/HDAC complex in cancer, we extended its protein-protein interaction network and identified a mutually exclusive pair within the complex. We then assessed the effects of SAHA on the disruption of the complex network through s ...[more]