Ontology highlight
ABSTRACT:
SUBMITTER: Toyoizumi T
PROVIDER: S-EPMC4223656 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Toyoizumi Taro T Kaneko Megumi M Stryker Michael P MP Miller Kenneth D KD
Neuron 20141022 2
Hebbian and homeostatic plasticity together refine neural circuitry, but their interactions are unclear. In most existing models, each form of plasticity directly modifies synaptic strength. Equilibrium is reached when the two are inducing equal and opposite changes. We show that such models cannot reproduce ocular dominance plasticity (ODP) because negative feedback from the slow homeostatic plasticity observed in ODP cannot stabilize the positive feedback of fast Hebbian plasticity. We propose ...[more]