Ultrafast propagation of ?-amyloid fibrils in oligomeric cloud.
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ABSTRACT:
SUBMITTER: Ogi H
PROVIDER: S-EPMC4223663 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Ultrafast propagation of β-amyloid fibrils in oligomeric cloud.
Ogi Hirotsugu H Fukukshima Masahiko M Hamada Hiroki H Noi Kentaro K Hirao Masahiko M Yagi Hisashi H Goto Yuji Y
Scientific reports 20141107
Interaction between monomer peptides and seeds is essential for clarifying the fibrillation mechanism of amyloid β (Aβ) peptides. We monitored the deposition reaction of Aβ(1-40) peptides on immobilized seeds grown from Aβ(1-42), which caused formation of oligomers in the early stage. The deposition reaction and fibrillation procedure were monitored throughout by novel total-internal-reflection-fluorescence microscopy with a quartz-crystal microbalance (TIRFM-QCM) system. This system allows simu ...[more]
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