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Antivirulence properties of an antifreeze protein.

ABSTRACT: As microbial drug-resistance increases, there is a critical need for new classes of compounds to combat infectious diseases. The Ixodes scapularis tick antifreeze glycoprotein, IAFGP, functions as an antivirulence agent against diverse bacteria, including methicillin-resistant Staphylococcus aureus. Recombinant IAFGP and a peptide, P1, derived from this protein bind to microbes and alter biofilm formation. Transgenic iafgp-expressing flies and mice challenged with bacteria, as well as wild-type animals administered P1, were resistant to infection, septic shock, or biofilm development on implanted catheter tubing. These data show that an antifreeze protein facilitates host control of bacterial infections and suggest therapeutic strategies for countering pathogens.

SUBMITTER: Heisig M

PROVIDER: S-EPMC4223805 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Antivirulence properties of an antifreeze protein.

Heisig Martin M Abraham Nabil M NM Liu Lei L Neelakanta Girish G Mattessich Sarah S Sultana Hameeda H Shang Zhengling Z Ansari Juliana M JM Killiam Charlotte C Walker Wendy W Cooley Lynn L Flavell Richard A RA Agaisse Herve H Fikrig Erol E

Cell reports 20141016 2

As microbial drug-resistance increases, there is a critical need for new classes of compounds to combat infectious diseases. The Ixodes scapularis tick antifreeze glycoprotein, IAFGP, functions as an antivirulence agent against diverse bacteria, including methicillin-resistant Staphylococcus aureus. Recombinant IAFGP and a peptide, P1, derived from this protein bind to microbes and alter biofilm formation. Transgenic iafgp-expressing flies and mice challenged with bacteria, as well as wild-type ...[more]

PMID: 25373896

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