The ensemble nature of allostery.
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ABSTRACT:
SUBMITTER: Motlagh HN
PROVIDER: S-EPMC4224315 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
The ensemble nature of allostery.
Motlagh Hesam N HN Wrabl James O JO Li Jing J Hilser Vincent J VJ
Nature 20140401 7496
Allostery is the process by which biological macromolecules (mostly proteins) transmit the effect of binding at one site to another, often distal, functional site, allowing for regulation of activity. Recent experimental observations demonstrating that allostery can be facilitated by dynamic and intrinsically disordered proteins have resulted in a new paradigm for understanding allosteric mechanisms, which focuses on the conformational ensemble and the statistical nature of the interactions resp ...[more]
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