Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC4224595 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Zhang Zhentao Z Song Mingke M Liu Xia X Kang Seong Su SS Kwon Il-Sun IS Duong Duc M DM Seyfried Nicholas T NT Hu William T WT Liu Zhixue Z Wang Jian-Zhi JZ Cheng Liming L Sun Yi E YE Yu Shan Ping SP Levey Allan I AI Ye Keqiang K
Nature medicine 20141019 11
Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a common feature of numerous aging-related neurodegenerative diseases, including Alzheimer's disease (AD). However, the molecular mechanisms mediating tau truncation and aggregation during aging remain elusive. Here we show that asparagine endopeptidase (AEP), a lysosomal cysteine proteinase, is activated during aging and proteolytically degrades tau, abolishes its microtubule assembly function, induces tau ag ...[more]