Effect of nano-scale curvature on the intrinsic blood coagulation system.
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ABSTRACT:
SUBMITTER: Kushida T
PROVIDER: S-EPMC4224616 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Effect of nano-scale curvature on the intrinsic blood coagulation system.
Kushida Takashi T Saha Krishnendu K Subramani Chandramouleeswaran C Nandwana Vikas V Rotello Vincent M VM
Nanoscale 20141101 23
The intrinsic coagulation activity of silica nanoparticles strongly depends on their surface curvature. Nanoparticles with higher surface curvature do not denature blood coagulation factor XII on its surface, providing a coagulation 'silent' surface, while nanoparticles with lower surface curvature show denaturation and concomitant coagulation. ...[more]
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