Ontology highlight
ABSTRACT:
SUBMITTER: Xie H
PROVIDER: S-EPMC4224644 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Xie Hui H Cui Zhuang Z Wang Long L Xia Zhuying Z Hu Yin Y Xian Lingling L Li Changjun C Xie Liang L Crane Janet J Wan Mei M Zhen Gehua G Bian Qin Q Yu Bin B Chang Weizhong W Qiu Tao T Pickarski Maureen M Duong Le Thi LT Windle Jolene J JJ Luo Xianghang X Liao Eryuan E Cao Xu X
Nature medicine 20141005 11
Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent study showed that a specific vessel subtype, strongly positive for CD31 and endomucin (CD31(hi)Emcn(hi)), couples angiogenesis and osteogenesis. Here, we found that platelet-derived growth factor-BB (PDGF-BB) secreted by preosteoclasts induces CD31(hi)Emcn(hi) vessel formation during bone modeling and remodeling. Mice with depletion of PDGF-BB in the tartrate-resistant acid phosphatase-positive cell lineage s ...[more]