Ontology highlight
ABSTRACT:
SUBMITTER: Rousakis A
PROVIDER: S-EPMC4225475 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Rousakis Aris A Vlassis Arsenios A Vlanti Anna A Patera Stefania S Thireos George G Syntichaki Popi P
Aging cell 20130628 5
The general control nonderepressible 2 (GCN2) kinase is a nutrient-sensing pathway that responds to amino acids deficiency and induces a genetic program to effectively maintain cellular homeostasis. Here we established the conserved role of Caenorhabditis elegans GCN-2 under amino acid limitation as a translation initiation factor 2 (eIF2) kinase. Using a combination of genetic and molecular approaches, we showed that GCN-2 kinase activity plays a central role in survival under nutrient stress a ...[more]