Ontology highlight
ABSTRACT:
SUBMITTER: Brigger D
PROVIDER: S-EPMC4225710 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Brigger Daniel D Torbett Bruce E BE Chen Joy J Fey Martin F MF Tschan Mario P MP
Biochemical and biophysical research communications 20130724 2
Autophagy is an intracellular bulk degradation process involved in cell survival upon stress induction, but also with a newly identified function in myeloid differentiation. The autophagy-related (ATG)8 protein family, including the GABARAP and LC3 subfamilies, is crucial for autophagosome biogenesis. In order to evaluate the significance of the GABARAPs in the pathogenesis of acute myeloid leukemia (AML), we compared their expression in primary AML patient samples, CD34(+) progenitor cells and ...[more]