Dataset Information

Genomic and transcriptomic analyses of the medicinal fungus Antrodia cinnamomea for its metabolite biosynthesis and sexual development.

ABSTRACT: Antrodia cinnamomea, a polyporus mushroom of Taiwan, has long been used as a remedy for cancer, hypertension, and hangover, with an annual market of over $100 million (US) in Taiwan. We obtained a 32.15-Mb genome draft containing 9,254 genes. Genome ontology enrichment and pathway analyses shed light on sexual development and the biosynthesis of sesquiterpenoids, triterpenoids, ergostanes, antroquinonol, and antrocamphin. We identified genes differentially expressed between mycelium and fruiting body and 242 proteins in the mevalonate pathway, terpenoid pathways, cytochrome P450s, and polyketide synthases, which may contribute to the production of medicinal secondary metabolites. Genes of secondary metabolite biosynthetic pathways showed expression enrichment for tissue-specific compounds, including 14-?-demethylase (CYP51F1) in fruiting body for converting lanostane to ergostane triterpenoids, coenzymes Q (COQ) for antroquinonol biosynthesis in mycelium, and polyketide synthase for antrocamphin biosynthesis in fruiting body. Our data will be useful for developing a strategy to increase the production of useful metabolites.

SUBMITTER: Lu MY

PROVIDER: S-EPMC4226107 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Genomic and transcriptomic analyses of the medicinal fungus Antrodia cinnamomea for its metabolite biosynthesis and sexual development.

Lu Mei-Yeh Jade MY Fan Wen-Lang WL Wang Woei-Fuh WF Chen Tingchun T Tang Yi-Ching YC Chu Fang-Hua FH Chang Tun-Tschu TT Wang Sheng-Yang SY Li Meng-yun MY Chen Yi-Hua YH Lin Ze-Shiang ZS Yang Kai-Jung KJ Chen Shih-May SM Teng Yu-Chuan YC Lin Yan-Liang YL Shaw Jei-Fu JF Wang Ting-Fang TF Li Wen-Hsiung WH

Proceedings of the National Academy of Sciences of the United States of America 20141021 44

Antrodia cinnamomea, a polyporus mushroom of Taiwan, has long been used as a remedy for cancer, hypertension, and hangover, with an annual market of over $100 million (US) in Taiwan. We obtained a 32.15-Mb genome draft containing 9,254 genes. Genome ontology enrichment and pathway analyses shed light on sexual development and the biosynthesis of sesquiterpenoids, triterpenoids, ergostanes, antroquinonol, and antrocamphin. We identified genes differentially expressed between mycelium and fruiting ...[more]

PMID: 25336756

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Dataset Information

Genomic and transcriptomic analyses of the medicinal fungus Antrodia cinnamomea for its metabolite biosynthesis and sexual development.

Publications

Genomic and transcriptomic analyses of the medicinal fungus Antrodia cinnamomea for its metabolite biosynthesis and sexual development.

Similar Datasets

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