Ontology highlight
ABSTRACT:
SUBMITTER: Lin C
PROVIDER: S-EPMC4226136 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Lin Changsheng C Ear Jason J Pavlova Yelena Y Mittal Yash Y Kufareva Irina I Ghassemian Majid M Abagyan Ruben R Garcia-Marcos Mikel M Ghosh Pradipta P
Science signaling 20110901 192
GIV (Gα-interacting vesicle-associated protein; also known as Girdin) enhances Akt activation downstream of multiple growth factor- and G protein (heterotrimeric guanosine 5'-triphosphate-binding protein)-coupled receptors to trigger cell migration and cancer invasion. We demonstrate that GIV is a tyrosine phosphoprotein that directly binds to and activates phosphoinositide 3-kinase (PI3K). Upon ligand stimulation of various receptors, GIV was phosphorylated at tyrosine-1764 and tyrosine-1798 by ...[more]