Ontology highlight
ABSTRACT:
SUBMITTER: Michaudel Q
PROVIDER: S-EPMC4226272 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Michaudel Quentin Q Journot Guillaume G Regueiro-Ren Alicia A Goswami Animesh A Guo Zhiwei Z Tully Thomas P TP Zou Lufeng L Ramabhadran Raghunath O RO Houk Kendall N KN Baran Phil S PS
Angewandte Chemie (International ed. in English) 20140922 45
Physicochemical properties constitute a key factor for the success of a drug candidate. Whereas many strategies to improve the physicochemical properties of small heterocycle-type leads exist, complex hydrocarbon skeletons are more challenging to derivatize because of the absence of functional groups. A variety of C-H oxidation methods have been explored on the betulin skeleton to improve the solubility of this very bioactive, yet poorly water-soluble, natural product. Capitalizing on the innate ...[more]