Targeting the estrogen pathway for the treatment and prevention of lung cancer.
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ABSTRACT:
SUBMITTER: Burns TF
PROVIDER: S-EPMC4226441 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Targeting the estrogen pathway for the treatment and prevention of lung cancer.
Burns Timothy F TF Stabile Laura P LP
Lung cancer management 20140201 1
The estrogen signaling pathway is involved in the biology of non-small-cell lung cancer and represents a novel therapeutic target for lung cancer. This is supported by epidemiological evidence, preclinical studies and recent data from clinical trials. Antiestrogens and inhibitors of estrogen synthesis have been shown to inhibit lung tumor growth as well as prevent lung tumorigenesis in preclinical models both <i>in vitro</i> and <i>in vivo</i>. Two clinical trials testing the effectiveness of ho ...[more]
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