Ontology highlight
ABSTRACT:
SUBMITTER: Dhakal KR
PROVIDER: S-EPMC4226470 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
PloS one 20141110 11
Stimulation of specific neurons expressing opsins in a targeted region to manipulate brain function has proved to be a powerful tool in neuroscience. However, the use of visible light for optogenetic stimulation is invasive due to low penetration depth and tissue damage owing to larger absorption and scattering. Here, we report, for the first time, in-depth non-scanning fiber-optic two-photon optogenetic stimulation (FO-TPOS) of neurons in-vivo in transgenic mouse models. In order to optimize th ...[more]