Ontology highlight
ABSTRACT:
SUBMITTER: Rosca EV
PROVIDER: S-EPMC4226498 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Rosca Elena V EV Penet Marie-France MF Mori Noriko N Koskimaki Jacob E JE Lee Esak E Pandey Niranjan B NB Bhujwalla Zaver M ZM Popel Aleksander S AS
PloS one 20141110 11
We investigated the application of a mimetic 20 amino acid peptide derived from type IV collagen for treatment of breast cancer. We showed that the peptide induced a decrease of proliferation, adhesion, and migration of endothelial and tumor cells in vitro. We also observed an inhibition of triple negative MDA-MB-231 xenograft growth by 75% relative to control when administered intraperitoneally for 27 days at 10 mg/kg. We monitored in vivo the changes in vascular properties throughout the treat ...[more]