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Germ-line transmitted, chromosomally integrated HHV-6 and classical Hodgkin lymphoma.

ABSTRACT: A unique feature of both human herpesvirus 6A and B (HHV-6A and B) among human herpesviruses is their ability to integrate into chromosomal telomeres. In some individuals integrated viral genomes are present in the germ-line and result in the vertical transmission of HHV-6; however, little is known about the disease associations of germ-line transmitted, chromosomally integrated HHV-6 (ciHHV-6). Recent publications suggest that HHV-6 is associated with classical Hodgkin lymphoma (cHL). Here we examine the prevalence of ciHHV-6 in 936 cases of cHL and 563 controls by screening with a duplex TaqMan assay and confirming with droplet digital PCR. ciHHV-6 was detected in 10/563 (1.8%) controls and in all but one individual the virus was HHV-6B. Amongst cases 16/936 (1.7%) harboured ciHHV-6, thus demonstrating no association between ciHHV-6 and risk of cHL.

SUBMITTER: Bell AJ

PROVIDER: S-EPMC4226568 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Germ-line transmitted, chromosomally integrated HHV-6 and classical Hodgkin lymphoma.

Bell Adam J AJ Gallagher Alice A Mottram Timothy T Lake Annette A Kane Eleanor V EV Lightfoot Tracy T Roman Eve E Jarrett Ruth F RF

PloS one 20141110 11

A unique feature of both human herpesvirus 6A and B (HHV-6A and B) among human herpesviruses is their ability to integrate into chromosomal telomeres. In some individuals integrated viral genomes are present in the germ-line and result in the vertical transmission of HHV-6; however, little is known about the disease associations of germ-line transmitted, chromosomally integrated HHV-6 (ciHHV-6). Recent publications suggest that HHV-6 is associated with classical Hodgkin lymphoma (cHL). Here we e ...[more]

PMID: 25384040

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