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The contribution of ??-tubulin curvature to microtubule dynamics.

ABSTRACT: Microtubules are dynamic polymers of ??-tubulin that form diverse cellular structures, such as the mitotic spindle for cell division, the backbone of neurons, and axonemes. To control the architecture of microtubule networks, microtubule-associated proteins (MAPs) and motor proteins regulate microtubule growth, shrinkage, and the transitions between these states. Recent evidence shows that many MAPs exert their effects by selectively binding to distinct conformations of polymerized or unpolymerized ??-tubulin. The ability of ??-tubulin to adopt distinct conformations contributes to the intrinsic polymerization dynamics of microtubules. ??-Tubulin conformation is a fundamental property that MAPs monitor and control to build proper microtubule networks.

SUBMITTER: Brouhard GJ

PROVIDER: S-EPMC4226729 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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The contribution of αβ-tubulin curvature to microtubule dynamics.

Brouhard Gary J GJ Rice Luke M LM

The Journal of cell biology 20141101 3

Microtubules are dynamic polymers of αβ-tubulin that form diverse cellular structures, such as the mitotic spindle for cell division, the backbone of neurons, and axonemes. To control the architecture of microtubule networks, microtubule-associated proteins (MAPs) and motor proteins regulate microtubule growth, shrinkage, and the transitions between these states. Recent evidence shows that many MAPs exert their effects by selectively binding to distinct conformations of polymerized or unpolymeri ...[more]

PMID: 25385183

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