Ontology highlight
ABSTRACT:
SUBMITTER: Santos JC
PROVIDER: S-EPMC4227165 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Santos Juliana C JC Funck Alexandre A Silva-Fernandes Isabelle J L IJ Rabenhorst Silvia H B SH Martinez Carlos A R CA Ribeiro Marcelo L ML
International journal of molecular sciences 20140929 10
It has been hypothesized that genetic variation in base excision repair (BER) might modify colorectal adenoma risk. Thus, we evaluated the influence of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in normal and tumor samples from patients with colorectal cancer. The results indicate a downregulation of OGG1 and an upregulation of XRCC1 expression in tumor tissue. Regarding the anatomical location of APE1, OGG1 and PARP-1, a decrease in gene expression was observ ...[more]