Ontology highlight
ABSTRACT:
SUBMITTER: Behjati S
PROVIDER: S-EPMC4227286 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Nature 20140629 7518
The somatic mutations present in the genome of a cell accumulate over the lifetime of a multicellular organism. These mutations can provide insights into the developmental lineage tree, the number of divisions that each cell has undergone and the mutational processes that have been operative. Here we describe whole genomes of clonal lines derived from multiple tissues of healthy mice. Using somatic base substitutions, we reconstructed the early cell divisions of each animal, demonstrating the co ...[more]