Ontology highlight
ABSTRACT:
SUBMITTER: Egger ME
PROVIDER: S-EPMC4227438 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Egger Michael E ME McNally Lacey R LR Nitz Jonathan J McMasters Kelly M KM Gomez-Gutierrez Jorge G JG
Human gene therapy. Clinical development 20140901 3
Melanoma exhibits variable resistance to the alkylating agent temozolomide (TMZ). We evaluated the potential of adenovirus expressing forkhead human transcription factor like 1 triple mutant (Ad-FKHRL1/TM) to sensitize melanoma cells to TMZ. Four melanoma cell lines were treated with Ad-FKHRL1/TM and TMZ, alone or in combination. Apoptosis was assessed by activation and inhibition of caspase pathway, nuclei fragmentation, and annexin V staining. The potential therapeutic efficacy of Ad-FKHRL1/TM ...[more]